Life Without Serotonin

serotonin Life Without Serotonin

I had no idea the link between serotonin and depression was in doubt. Very interesting:

Via Dormivigilia, I came across a fascinating paper about a man who suffered from a severe lack of monoamine neurotransmitters (dopamine, serotonin etc.) as a result of a genetic mutation. [...]

Overall, though, the biggest finding here was a non-finding: this patient wasn’t depressed, despite having much reduced serotonin levels. This is further evidence that serotonin isn’t the “happy chemical” in any simple sense.

On the other hand, the similarities between his symptoms and some of the symptoms of depression suggest that serotonin is doing something in that disorder. This fits with existing evidence from tryptophan depletion studies showing that low serotonin doesn’t cause depression in most people, but does re-activate symptoms in people with a history of the disease. As I said, it’s complicated…

Neuroskeptic: Life Without Serotonin

See also:

Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

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Obliquity: sometimes it’s better to try the indirect approach

Oblique

Obliquity describes the process of achieving objectives indirectly, such as the financial success that comes from a real commitment to business. And obliquity is ubiquitous – it can even be applied to happiness. It has long been suspected that the happiest people are not those who pursue it directly. John Stuart Mill was the strongest exponent of utilitarianism, the notion that the goal of mankind was the greatest happiness of the greatest number of people. Yet towards the end of his (far from happy) life, Mill found that ‘this end was only to be attained by not making it the direct end. Those only are happy (I thought) who have their minds fixed on some object other than their own happiness – on some art or pursuit, followed not as a means, but as itself an ideal end. Aiming thus at something else, they find happiness by the way.’

Surely obliquity goes against everything we’ve been taught? Isn’t it true that you must do better if you set out to maximise something – happiness, wealth, profit – than if you don’t? Surprisingly, the answer is no. Life is too complex and uncertain for us to be able to predict and follow the most direct perceived route to success. Our knowledge is always imperfect, and events are influenced by the unpredictability of other people and organisations. Instead, our objectives are best achieved by a more meandering approach that enables us to adapt our strategy to changing situations. And we learn about the nature of our objectives and the means of achieving them through a process of experiment and discovery.

Management Today: Obliquity: the roundabout route to success

See also: Kay’s previous Financial Times article on the subject.

(via Relevant History)

(Photo credit: http://www.flickr.com/photos/mrhayata/1875046344/ / CC)

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Shopping for Happiness? Get a Massage, Forget the Flat-Screen TV

Massage

Consumers found that satisfaction with “experiential purchases” — from massages to family vacations — starts high and increases over time. In contrast, spending money on material things feels good at first, but actually makes people less happy in the end, says Thomas Gilovich, Cornell University professor of psychology and Travis J. Carter, Cornell Ph.D. ‘10.

Science Daily: Shopping for Happiness? Get a Massage, Forget the Flat-Screen TV

See also: Transumers.

(Photo credit: Thomas Wanhoff / CC)

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Americans’ job satisfaction falls to record low

Even Americans who are lucky enough to have work in this economy are becoming more unhappy with their jobs, according to a new survey that found only 45 percent of Americans are satisfied with their work.

That was the lowest level ever recorded by the Conference Board research group in more than 22 years of studying the issue. In 2008, 49 percent of those surveyed reported satisfaction with their jobs. [...]

Workers have grown steadily more unhappy for a variety of reasons:

- Fewer workers consider their jobs to be interesting.

- Incomes have not kept up with inflation.

- The soaring cost of health insurance has eaten into workers’ take-home pay.

AP: Americans’ job satisfaction falls to record low

(via Cryptogon)

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Researchers discover that stress isn’t a modern invention

Using modern forensic technology and a decidedly modern understanding of biochemistry, researchers from The University of Western Ontario have taken a look at stress levels in pre-Colombian Peru; their findings are summarized in an upcoming edition of the Journal of Archaeological Science. They found that stress has plagued humanity for at least 1500 years. The researchers were able to get the dead to give up not only their final secrets, but an understanding of their life for a few years before they shuffled off this mortal coil.

When humans get stressed, our bodies release a chemical known as cortisol, which appears in our blood, our urine, and even our hair. Of those three, hair is only one stands the test of over 1000 years of time, and provides a short history of the last years that its owner had. By examining hair strands from 10 individuals at five different dig sites in Peru, the researchers were able to determine how stressed people were, using the levels of cortisol in segments of their hair.

Ars Technica: The prehistory of stress

(Thanks Paul)

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Research Shows Chronically Ill Patients Might Be Happier if They Give Up Hope

Holding on to hope may not make patients happier as they deal with chronic illness or diseases, according to a new study by University of Michigan Health System researchers.

“Hope is an important part of happiness,” said Peter A. Ubel, M.D., director of the U-M Center for Behavioral and Decision Sciences in Medicine and one of the authors of the happily hopeless study, “but there’s a dark side of hope. Sometimes, if hope makes people put off getting on with their life, it can get in the way of happiness.”

The results showed that people do not adapt well to situations if they are believed to be short-term. Ubel and his co-authors — both from U-M and Carnegie Mellon University — studied patients who had new colostomies: their colons were removed and they had to have bowel movements in a pouch that lies
outside their body.

At the time they received their colostomy, some patients were told that the colostomy was reversible — that they would undergo a second operation to reconnect their bowels after several months. Others were told that the colostomy was permanent and that they would never have normal bowel function again. The second group — the one without hope — reported being happier over the next six months than those with reversible colostomies.

Reuters: Research Shows Chronically Ill Patients Might Be Happier if They Give Up Hope

(via Disinfo)

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‘Culture Of We’ Buffers Genetic Tendency To Depression

A genetic tendency to depression is much less likely to be realized in a culture centered on collectivistic rather than individualistic values, according to a new Northwestern University study.

In other words, a genetic vulnerability to depression is much more likely to be realized in a Western culture than an East Asian culture that is more about we than me-me-me.

The study coming out of the growing field of cultural neuroscience takes a global look at mental health across social groups and nations.

Depression, research overwhelmingly shows, results from genes, environment and the interplay between the two. One of the most profound ways that people across cultural groups differ markedly, cultural psychology demonstrates, is in how they think of themselves.

“People from highly individualistic cultures like the United States and Western Europe are more likely to value uniqueness over harmony, expression over agreement, and to define themselves as unique or different from the group,” said Joan Chiao, the lead author of the study and assistant professor of psychology in the Weinberg College of Arts and Sciences at Northwestern.

In contrast, people from collectivist cultures are more likely to value social harmony over individuality. “Relative to people in an individualistic culture, they are more likely to endorse behaviors that increase group cohesion and interdependence,” Chiao said.

Science Daily: ‘Culture Of We’ Buffers Genetic Tendency To Depression

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Depression’s Evolutionary Roots

Depression seems to pose an evolutionary paradox. Research in the US and other countries estimates that between 30 to 50 percent of people have met current psychiatric diagnostic criteria for major depressive disorder sometime in their lives. But the brain plays crucial roles in promoting survival and reproduction, so the pressures of evolution should have left our brains resistant to such high rates of malfunction. Mental disorders should generally be rare — why isn’t depression? [...]

In an article recently published in Psychological Review, we argue that depression is in fact an adaptation, a state of mind which brings real costs, but also brings real benefits. [...]

So what could be so useful about depression? Depressed people often think intensely about their problems. These thoughts are called ruminations; they are persistent and depressed people have difficulty thinking about anything else. Numerous studies have also shown that this thinking style is often highly analytical. They dwell on a complex problem, breaking it down into smaller components, which are considered one at a time.

This analytical style of thought, of course, can be very productive. Each component is not as difficult, so the problem becomes more tractable. Indeed, when you are faced with a difficult problem, such as a math problem, feeling depressed is often a useful response that may help you analyze and solve it. For instance, in some of our research, we have found evidence that people who get more depressed while they are working on complex problems in an intelligence test tend to score higher on the test. [...]

Depression is nature’s way of telling you that you’ve got complex social problems that the mind is intent on solving. Therapies should try to encourage depressive rumination rather than try to stop it, and they should focus on trying to help people solve the problems that trigger their bouts of depression. (There are several effective therapies that focus on just this.) It is also essential, in instances where there is resistance to discussing ruminations, that the therapist try to identify and dismantle those barriers.

For those who think modernity or civilization or technology is the problem:

Or, perhaps, depression might be like obesity — a problem that arises because modern conditions are so different from those in which we evolved. Homo sapiens did not evolve with cookies and soda at the fingertips. Yet this is not a satisfactory explanation either. The symptoms of depression have been found in every culture which has been carefully examined, including small-scale societies, such as the Ache of Paraguay and the !Kung of southern Africa — societies where people are thought to live in environments similar to those that prevailed in our evolutionary past.

Scientific American: Depression’s Evolutionary Roots

(via Theoretick)

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How to buy happiness

MSN has an article on how to spend your money to optimize happiness.

1. Relationships

2. Time

3. Health

4. Learning

5. Debt relief

6. Giveaways

7. Security

MSN: 7 smart ways to buy happiness

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Happiness: It Really Is Contagious

Turns out, misery may not love company — but happiness does, research suggests.

A new study by researchers at Harvard University and the University of California, San Diego documents how happiness spreads through social networks.

They found that when a person becomes happy, a friend living close by has a 25 percent higher chance of becoming happy themselves. A spouse experiences an 8 percent increased chance and for next-door neighbors, it’s 34 percent.

“Everyday interactions we have with other people are definitely contagious, in terms of happiness,” says Nicholas Christakis, a professor at Harvard Medical School and an author of the study.

Perhaps more surprising, Christakis says, is that the effect extends beyond the people we come into contact with. When one person becomes happy, the social network effect can spread up to 3 degrees — reaching friends of friends.

NPR: Happiness: It Really Is Contagious

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5 Things You Think Will Make You Happy (But Won’t)

Fame
Wealth
Beauty
Genius
Power

Cracked: 5 Things You Think Will Make You Happy (But Won’t)

(via Justin)

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Happiness, freedom, and control

Two quotes on my mind tonight:

1. From The Job interviews with William S. Burroughs:

Q: Are they happy anywhere?

A: They’re certainly happier in Spain with all the poverty than they are in Sweden with all the prosperity and their high living standard.

Q: But then, Spain is a good example of a highly controlled country with a repressive government, a religious bugbear – just about everything…

A: Just about everything. They have all sorts of troubles. But you see, poverty keeps people busy. You see happiness there in the faces of the people on the streets that you do not see on Swedish streets.

This interview took place in the 70s when Spain was still under Franco. With regard to the question of “being busy” read this and consider what many (most?) of us are “busy” doing in modern post-industrial society.

2. Reality Sandwich interview with R.U. Sirius:

Q: It seems equally possible that we will be thrust into some kind of totalitarian technological hell in which our every movement is watched and our perceptions are closely monitored, a la A Scanner Darkly or 1984. It’s interesting to observe how a force as powerful as technology can simultaneously invoke great dread or great hope in people based on different perspectives of its usefulness in our lives.

A: Yeah, I think that’s actually more of a parallel vision than an opposite vision. These technologies could solve problems and not be disastrous in a physical sense, but they seem to almost inevitably bring on the death of the Western concept of privacy. The scenario could be hellish, considering the current political dynamics: authoritarian tendencies married to paranoias about security are at war with authoritarian outsider anti-imperialists who hate technology and modernity.

But I don’t think the scenario will necessarily be particularly hellish. It could easily resolve into a very liberal control system. In some interview during the ’80s, someone asked William Burroughs about Brave New World and he said (in that great Burroughs voice), “I think it would be an improvement.” I can imagine a very liberal society – pampered by machines – in which people are free to carry on wild festivities in the hippie/pagan/Burning Man traditions, or do just about whatever pleases them, and where the margins on behavior are set really wide, but if you slip over those margins, everybody immediately knows about it and your brain is instantly corrected so that you can’t do that taboo thing again. Instant rehab!

Which of course makes me think of the movie Zardoz

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Why boredom is exhausting

By now you’ve probably seen this story floating around about how doodling may improve concentration, but I’m particularly interested in this part of the story:

When people are bored they have high levels of brain activity, Andrade says. “When you’re bored, you think nothing much is going on, but actually your brain is looking for something to do.”

So we daydream. But daydreaming takes considerable mental effort, particularly when we get stuck in a daydream. “So that sucks mental resources and energy away from the other task we’re meant to be doing,” Andrade says.

Which explains why we can feel so tired and burned out after a long, boring but easy day at work or school – or many successive days of boredom.

Full Story: Canada.com

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20 Unhappiest Cities in America

I live in the unhappiest city in America:

Portland, Ore.
St. Louis, Mo.
New Orleans, La.
Detroit, Mich.
Cleveland, Ohio
Jacksonville, Fla.
Las Vegas, Nev.
Nashville-Davidson, Tenn.
Cincinnati, Ohio
Atlanta, Ga.
Milwaukee, Wis.
Sacramento, Calif.
Kansas City, Mo.
Pittsburgh, Pa.
Memphis, Tenn.
Indianapolis city, Ind.
Louisville, Ky.
Tucson, Ariz.
Minneapolis, Minn.
Seattle, Wash.

Full Story: Business Week

(via Tara)

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Quality of Life entry on Appropedia

Appropedia’s entry on happiness research and happiness economics. Lots of research quoted.

See also:

Take Back Your Time

How to Use Your Character Strengths

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‘I Love the World’

video77667a5598fd I Love the World

Another one for today. Can’t get much better than this! xo
Kudos to agency 72andSunny and creative director Glenn Cole for this inspirational piece of advertising.

Amazing what a power a positive note can have on one’s day. When’s the last time you made a stranger feel this way?

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Seven tips for waking up feeling refreshed

sleep

1. Keep a schedule
2. Eat light in the evening
3. Have things you WANT to do during the day
4. Plan your day
5. Drink water before bed and upon waking
6. Exercise
7. Have some private time in the morning

Full Story: Dumb Little Man.

(via Robot Wisdom).

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Against Happiness: is depression actually good for us?

The English professor at Wake Forest University wants to be clear that he is not “romanticizing” clinical depression and that he believes it is a serious condition that should be treated.

But he worries that today’s cornucopia of antidepressants – used to treat even what he calls “mild to moderate sadness” – might make “sweet sorrow” a thing of the past.

“And if that happens, I wonder, what will the future hold? Will our culture become less vital? Will it become less creative?” he asks.

[...]

We can picture this in the primitive world. While the healthy bodies of the tribe were out mindlessly hacking beasts or other humans, the melancholy soul remained behind brooding in a cave or under a tree. There he imagined new structures, oval and amber, or fresh verbal rhythms, sacred summonings, or songs superior to even those of the birds. Envisioning these things, and more, this melancholy malingerer became just as useful for his culture as did the hunters and the gatherers for theirs. He pushed his world ahead. He moved it forward. He dwelled always in the insecure realm of the avant-garde.

This primitive visionary was the first of many such avant-garde melancholics. Of course not all innovators are melancholy, and not all melancholy souls are innovative. However, the scientifically proved relationship between genius and depression, between gloom and greatness suggests that the majority of our cultural innovators, ranging from the ancient dreamer in the bush to the more recent Dadaist in the city, have grounded their originality in the melancholy mood. We can of course by now understand why.

Full Story: NPR.

Counter arguments: Hedonistic Imperative.

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Use your words, they’re steps to the soul

2003712698 541fff5fdb m Use your words, theyre steps to the soulI’m just reading over some design sites trying to fill in my afternoon here and came across this interesting piece on the wonderful A Brief Message:

Your most intuitive, meaningful, and devastatingly clever design is worthless – unless it’s shallow enough to appeal in the first five seconds.

Most of the time, that’s all you’ll get before they walk, click, or turn away.

Every day, millions go window shopping. Flip through magazines or channels. Walk bookstore aisles, quickly judging each book… by its cover.

Ask us what we’re looking for, however, and most of us won’t know. Though we can’t articulate what we want, it’s clear that we all know it when we see it. Design helps us see it.

With more email, more channels, and more data, we’re left with less time. And more and more, we’re forced to make decisions in a split second, often based on less information than before.

Though we may think of design as a process that runs deep, often it works at very superficial levels.

It’s here that design plays an increasingly important role: communicating a concept, feeling, or attitude in a moment. It condenses the larger body of information that we’re no longer willing (or able) to attend to, and conveys it instantly. It’s what good design has always done, and it’s more important than ever.

This makes me wonder about the state of selling things as quickly as possible. Not just products/services, but people, too. The douchebag New Jersey kids with spray-on tans, the ditzy bar hussies who spend too much time thinking about their hair, people in general with no practical experience with their own subjective opinions.

It has to do with this post I recently made on the difference between how Americans the French can tell when they’re full. One group grows up being told to eat everything on their plate, and feels dissatisfied till they do. The other, they eat and drink only until they’re comfortable and sense they’re comfortable capacity has been met.

After observing the whole national movement which garnered around the Internet vs Scientology, I have to wonder: how do we inspire a Fight Club-like knowledge of subjective value and worth?

Read the rest of this entry »

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Why Perfect Dates Make Lousy Partners

The best “catches” in dating land may be the worst choices in the long-run, new research shows.

Popular people who monitor themselves carefully in social situations and thereby appear to be the most socially appropriate are often highly sought after as romantic partners, a study finds, but these people show less satisfaction and commitment in relationships than socially-awkward people.

[...]

Fortunately, Roloff said, self-monitoring is normally distributed, so most people end up with a partner who falls somewhere in the middle. A person who moderately self-monitors may have great social skills and the ability to be unguarded with their partner when necessary.

Full Story: Live Science.

(via Robot Wisdom).

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‘The Origin of Emotions’

Mark Devon, the author:

I began thinking about emotions while studying evolutionary theory at Harvard University.

Learning that adaptations do not evolve unless they help survival, I reasoned that each emotion must have a purpose that helped survival. If I could identify an emotion’s trigger, I could also identify its purpose.

Applying that thought to each emotion, I wrote The Origin of Emotions. [Available as a free PDF download. Or you can purchase a hardcopy for ease of reading.]

The following are excerpts from the book:

‘Maternal love stops when a child is 33 months old. Mothers maximize their reproduction by focusing on the next child when the current child can feed itself. By 33 months, children can feed themselves if food is available. They can walk and their first set of teeth have completed eruption.’

‘Men only love a woman for 42 months, which covers 9 months of gestation and 33 months of post-natal care. Both sexes maximize reproduction by starting a new reproductive cycle with a new partner when a child can feed itself.’

‘Revenge encourages victims of rule breaking to always retaliate, whether it helps them or not. The more victims retaliate, the fewer rule breakers there are. The fewer rule breakers there are, the more efficient a group is.’

‘Pride is triggered by higher rank, not high rank. Rookies feel pride, but veteran all-stars do not. Recent nursing graduates feel pride, but doctors nearing retirement do not.’

‘Humiliation is triggered by lower rank, not low rank. The only criminals who feel humiliation are first-time offenders. Every CEO feels humiliation when they retire.’

‘You feel affection when you see or hear features that separate humans from other primates, such as the sight of white eyes or the sound of talking.’

‘When you maximize your happiness, you do what is best for the species.’

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The Happiness Project

New blog on happiness:

I’m working on a book, THE HAPPINESS PROJECT–a memoir about the year I spent test-driving every principle, tip, theory, and scientific study I could find, whether from Aristotle or St. Therese or Martin Seligman or Oprah. THE HAPPINESS PROJECT will gather these rules for living and report on what works and what doesn’t. On this daily blog, I recount some of my adventures and insights as I grapple with the challenge of being happier.

The Happiness Project.

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Think Negative! Oprah, it’s time to come clean about The Secret.

Cerulo, a professor at Rutgers University, wrote a book last year called Never Saw It Coming. In it, she argues that we are individually, institutionally, and societally hellbent on wishful thinking. The Secret tells us to visualize best-case scenarios and banish negative ones from our minds. Never Saw It Coming says that’s what we’ve been doing all along-and we get blindsided by even the most foreseeable disasters because of it.

In her research, Cerulo found that when most of us look out at the world and plan for our future, we fuzz out our vision of any failure, fluke, disease, or disaster on the horizon. Instead, we focus on an ideal future, we burnish our best memories, and, well, we watch a lot of your show. Meanwhile, we’re inarticulate about worst-case scenarios. Just thinking about them makes us nervous and uncomfortable.

Full Story: Slate

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A proposal to classify happiness as a psychiatric disorder

Abstract:

It is proposed that happiness be classified as a psychiatric disorder and be included in future editions of the major diagnostic manuals under the new name: major affective disorder, pleasant type. In a review of the relevant literature it is shown that happiness is statistically abnormal, consists of a discrete cluster of symptoms, is associated with a range of cognitive abnormalities, and probably reflects the abnormal functioning of the central nervous system. One possible objection to this proposal remains–that happiness is not negatively valued. However, this objection is dismissed as scientifically irrelevant.

From: JME.

(via Robot Wisdom)

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Whipping therapy cures depression and suicide crises

Russian scientists from the city of Novosibirsk, Siberia, made a sensational report at the international conference devoted to new methods of treatment and rehabilitation in narcology. The report was called “Methods of painful impact to treat addictive behavior.”

Siberian scientists believe that addiction to alcohol and narcotics, as well as depression, suicidal thoughts and psychosomatic diseases occur when an individual loses his or her interest in life. The absence of the will to live is caused with decreasing production of endorphins – the substance, which is known as the hormone of happiness. If a depressed individual receives a physical punishment, whipping that is, it will stir up endorphin receptors, activate the ‘production of happiness’ and eventually remove depressive feelings.

Full Story: Pravda.

(Thanks Danny Chaoflux).

William S. Burroughs:

Danger is a biological necessity for humans, just like sleep and dreams. If you face death, for that time you are immortal. For the Western middle classes, danger is a rarity and erupts only with a sudden, random shock. And yet we are in danger at all times, since our death exists. Is there a technique for confronting death without immediate physical danger? (quoted from Hashisheen: The End of Law)

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Technoccult Presents

<a href="http://psychetect.bandcamp.com/album/return-to-the-wasteland">Awakening by Psychetect</a>

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